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D.NirenbergS.WangB.et al (2020)

Methylation, acetylation, and amino acid conjugation prepare toxins for bile release

Similar results were found in a COS-7 model that overexpressed active human OPH (COS-7-OPH)

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In endothelial cells, high UA levels decreases NO production [46, 49, 50], increases arginase activity [49], and suppresses insulin-stimulated phosphorylation of PKB (Akt) and eNOS [51]