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(PubMed) Misu H, Takamura T, Takayama H, et al

Since the introduction of kava consumption to Western society, other solvents have been used to optimize the kavalactone extraction yield, often resulting in higher concentration of these active compounds, but also other potentially less desirable (even dangerous, see later discussion) flavokavains and alkaloids [15,32,35,38,40,41]

They increase the amount of TMA in the body

doi: 10.1111/jphp.12867 456 El-ShafeyAAMHegabMHASeliemMMEBarakatAMAMostafaNEAbdel-MaksoudHAet al

Erythroferrone A hormone secreted by erythroid progenitors in the bone marrow that increases iron availability by suppressing hepcidin expression in the liver