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The ascorbate-glutathione pathway (Halliwell-Asada cycle) is an indispensible component of the ROS homeostasis mechanism of plants

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7.2 Polyphenols: orchestrators of redox balance and metabolic homeostasis Polyphenols mitigate ALD by chelating iron to block Fenton reaction-driven hydroxyl radical generation, while epigenetic modulation through SIRT1-mediated deacetylation of NF-B and histones further suppresses inflammation (Song et al., 2020)