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Likewise, loss-of-function mutations in another Ca 2+ -channel Transient receptor potential cation channel, subfamily M, member 2 (TRPM2) are also associated with human bipolar disorder and Trpm2 null mice display manic-like behaviours [29]

Many patients combine this blend with complementary therapies for synergistic effects across multiple aging pathways

Mol Neurodegener 16(1):71 Marchetti B et al (2022) Reframing dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: therapeutical implications

These transitions are regulated by key transcription factors, such as ID2, T-bet, Eomes and Blimp-1, which balance effector function and memory formation 8

The role of the microbiota in DNL and NAFLD will be discussed in a later section