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In other words, greater cognitive decline presents a greater challenge for reversal and enhancement

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At the cellular level, MS represents an abnormal balance between effector and regulatory T cells, including aberrant pro-inflammatory functions of IFN- + TNF- + CXCR3 + Tbet + Th1, IL-17 + CCR6 + CD161 + ROR t + Th17 and GM-CSF + T cells (44), while IL10 + CD25 high CD127 - FOXP3 + Tregs present deficient functions