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In fact, the treatment of healthy and tumor cells with CAP under conditions of selective tumor-cell death stimulates largely similar types of transcriptional response: the up-regulation of the p53 pathway, KRAS signaling, the UV response, TNF-alpha signaling, and apoptosis-related processes 99

The medium was changed for the first time, after 72 h

doi: 10.1016/s0891-5849(97)00286-4 239 Santos Duarte LanaJ

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Masarova L, Cortes JE, Pemmaraju N, Jabbour E, Bose P, Ohanian M, Zhou L, Pierce S, Gergis R, Borthakur G , Estrov Z, Garcia-Manero G, Kantarjian HM, Verstovsek S, Daver NG