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In turn, these compromised mitochondria produce excess ROS, which further stimulates pro-inflammatory gene expression through MAPK and NF-B signaling, creating a self-reinforcing feedback loop that amplifies the inflammatory cytokines response

Altered expression of EAAT2 in severe mental illness The glutamate hypothesis of schizophrenia is based on observations that administration of the NMDA receptor antagonist phencyclidine (PCP) induces schizophrenia-like symptoms, including psychosis and cognitive impairment

Abstract Glutathione synthetase deficiency is a rare autosomal recessive disorder resulting in low levels of glutathione and an increased susceptibility to oxidative stress

A vehicle-controlled clinical trial

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