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& Navas-Martin, S

Third, clinical efforts should include establishing multicenter FRDA biobanks to validate associations between ferroptosis biomarkers (such as ACSL4 and mitochondrial iron content) and clinical measures including SARA ataxia scores and left ventricular ejection fraction, and conducting combination trials of ferroptosis inhibitors with ironsulfur cluster metabolism regulators to evaluate synergistic improvement in neurologic and cardiac function

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Most community protocols wait longer than that - typically 8 weeks of tirzepatide alone before adding cagrilintide

Typical oral doses range from 5001500 mg daily in divided doses to account for this limitation