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Neuro Endocrinol Lett 27:615622 Maes M, Mihaylova I, Leunis JC (2007) Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and dep

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Furthermore, decreased saccharin preference (anhedonia), which is a key symptom of melancholia, was induced by the administration of LPS in a rodent model of depressive-like behavior [106]