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In RA synovial cells, the mTOR signaling pathway is abnormally activated to participate in the regulation of RA FLS invasion [104]

Pre-treatment median (IQR) levels of S-HBs, M-HBs and L-HBs were 3681 (1240-7184), 813 (260-2262) and 5 (1-12) ng/ml, respectively

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We then compared the mutation frequencies of the top 20 HRGs identified by RL-GenRisk before and after PPI network perturbation and created dot plots for visualization (Fig

Pharmacological inhibition of JNK prevented 4-HNE-induced LC3-II formation, suggesting that 4-HNE triggered autophagic responses could be partly attributed to ER stress [155]