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Incretin-based therapy for diabetes prevention in patients with obesity In agreement with what has been previously shown for any weight-lowering lifestyle intervention and medication, regardless of their mechanism of action 18 , incretin-based AOM have been associated with amelioration of glucose metabolism and T2D prevention (Fig

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Aggregation of these disrupts normal cellular processes, such as protein degradation, resulting in cellular stress and, ultimately, cell death ( 2.2 Mitochondrial dysfunction Mitochondria are necessary for cellular energy, but in neurodegenerative diseases, mitochondrial dysfunction is a major factor in neuronal damage

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However, the use of blinded evaluators (dermatologists who didn't know which photos were "before" and "after") and AI-assisted assessment helps reduce subjective bias in the results