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Indeed, adenoviral HO-1 overexpression via intracardiac administration, resulting in both aortic and liver overexpression, confers protection against atherosclerosis whereas tail vein administration, only resulting in hepatic but not aortic overexpression, does not (Juan et al., Endothelial cells The vessels contain a monolayer of endothelial cells which represent the first cellular component that any infiltrating lipid or inflammatory cell encounter as they enter the vascular wall