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10.1016/j.pharmthera.2017.02.041 21

Standard Daily Requirements vs

This undergoes a transposition reaction coupled with ring expansion, ultimately decomposing into several breakdown products, including enamine propenal derivatives ( The hydroxyl radical also induces base-specific damage

Furthermore, the selective IKK inhibitor SC-514 inhibited the IB degradation to inactivate the NF-B signal, further triggering to impair RANKL (receptor activator of nuclear factor-B ligand)-induced osteoclastogenesis [119], which was further supported by Thummuri's study showing that inhibition of IKK by abietic acid attenuated RANKL-induced osteoporosis [120]