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Swelling is often mild and temporary but can be noticeable

Together, these above-mentioned ionic signals are tightly linked with the neuronal activity generating a wide array of responses, including activation of plasmalemmal homeostatic transporters, processing, and secretion of a wide variety of neurotransmitters precursors, neuromodulators, cytokines, metabolic substrate, trophic factors and metabolic substrates (Augusto-Oliveira et al., 2020)

Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimers disease

PMID: 33652173

In summary, previous results support a model where LBP gradually builds up in clearly defined brain regions, leading to neuronal death