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Several authors have demonstrated that whole-blood and red blood cell enzyme activity decreases throughout pregnancy due to Se deficiency in the blood

Peritoneal dialysis has been demonstrated to decrease peripheral blood glutamate levels in rats with cerebral ischemia (Godino Mdel et al., 2013)

In BV2 cells, the inflammatory factor IL-6 was upregulated after FAC exposure, in turn, DMT1 was upregulated and FPN1 was downregulated following 24 hours of IL-6 stimulation, which resulted in iron overload ( Oxidative stress and autophagy were reported to participate in microglial ferroptosis likewise

PMID 19523113

The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis