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Angiotensin-converting enzyme 2 (ACE2), which has been confirmed to have a high affinity with the coronavirus spike protein, is expressed not merely in the lung but also in the extrapulmonary organs including the gastrointestinal (GI) tract (Shang et al., 2020

A2A and dopamine D 2 receptors form functional heteromeric complexes inducing allosteric inhibition, and A2A receptor activation results in motor inhibition (Beggiato et al