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Cxcr1/2 antagonism with cxcl8 interleukin-8 analogue cxcl8(372)K11r G31p restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis

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SHMT2 also exerts influence on tumor cells ability to migrate and proliferate, supporting metabolic adaptations through Akt2 and n-Myc activation in human neuroblastoma cells [121], or hypoxia inducible factor 1 (HIF-1) activation in human gastric cancer cells [122]