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Moreover, metabolites like pyruvate, lactate, glutamine, oleic acid, and cystine in the circulation all potentially help detached cancer cells defend against oxidative stress 8 and further contribute to anoikis resistance

The survival of breast cancer cells, particularly TNBC cells, is cystine-dependent

*Correspondence: Zheng Yuan, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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By revealing the role of GPX2 in endoderm progenitor differentiation, we provide insights into the molecular mechanisms underlying lineage specification and cellular plasticity