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4 patients experienced (during the second year of treatment) an effect ON/OFF of the treatment when they forgot or wanted to stop the treatment

BMI 26-27: 7.5 mg

5-HT 5-hydroxytryptamine 5-MT 5-Methoxytryptamine 6-OHM 6-Hydroxymelatonin 8-OHdG 8-hydroxydeoxyguanosine AANAT Aralkylamine N- acetyltransferase A Amyloid peptide Acetyl CoA Acetyl coenzyme A AD Alzheimers disease AFMK N1-Acetyl-N2-formyl-5-methoxykynuramine AMD Age-related macular degeneration AMK N1-Acetyl-5-methoxykynuramine Apo-E Apolipoprotein-E ARE Antioxidant response element ASMT Acetyl serotonin O-methyltransferase DAMP Damage-associated molecular pattern DRP1 Dynamin-related protein 1 EMT Epithelial to mesenchymal transition GPx Glutathione peroxidase GRd Glutathione reductase H 2 O 2 Hydrogen peroxide HIF-1 Hypoxia inducible factor-1 alpha iBRB Inner blood retinal barrier ICAM-1 Intercellular adhesion molecule 1 IFN- Interferon IB Inhibitor B IL Interleukin IRDS Intrinsically disordered regions of proteins Keap1 Kelch-like ECH-associated protein 1 MMP Matrix metalloproteinase NF-kB Nuclear factor kB NLRP3 NOD-like receptor pyrin domain containing protein NO Nitric oxide Nrf2 Nuclear factor erythroid 2-related factor 2 NRL NOD-like receptor O 2 - Superoxide anion radical oBRB Outer blood retinal barrier OH Hydroxyl radical ONOO Peroxynitrite anion OXPHOS Oxidative phosphorylation PRR Pattern recognition receptor PS Phase separation PTM Post-translational modification PUFA Polyunsaturated fatty acid ROS Reactive oxygen species RPE Retinal pigment epithelium SERCA 2 Sarco/endoplasmic reticulum calcium 2 ATPase SIRT1 Sirtuin 1 SOD Superoxide dismutase TCA Tricarboxylic acid cycle TGF- Transforming growth factor TLR Toll-like receptor VEGF Vascular endothelial growth factor Glossary References 1

Outpatient OTs at MGH have experienced some success in the treatment of FD using guidance from current literature