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DAPI-stained nuclei with blue fluorescence were viewed under laser confocal microscope (LSM 510

Vitamin B 12 is needed to prevent anemia, since making porphyrin and heme in mitochondria for producing hemoglobin in red blood cells depends on succinyl-CoA made by vitamin B 12

The resulting nano-CLIPTACs induced potent, dose-dependent degradation of EML4-ALK fusion protein with a DC of 175.37 53.24 nM, significantly outperforming both the unencapsulated precursors (DC = 359.03 48.29 nM) and the pre-assembled WZ42@cRGD-LPs (DC = 620.10 176.90 nM)