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People with diabetes who take metformin are at higher risk of developing B12 deficiency because this drug can reduce the absorption of vitamin B12 in the body B12 deficiency impairs motor and sensory nerve function

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Such inflammatory molecules induce cell apoptosis, senescence and autophagy and upregulate the synthesis of MMPs (1, 3, 7, 9 and 13) and ADAMTS (1, 4, 5, 9 and 15) through NPCs, thus leading to ECMs catabolism (Risbud and Shapiro, 2014)