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Additionally, we induced iron accumulation in PD neurons using ferric ammonium citrate (FAC) in combination with 6-OHDA in both mono- and co-cultures to assess whether SO EO and (+)-limonene mitigated iron-mediated oxidative stress

So, going back to kind of the old free radical theory of aging theory that basically the more free radicals that you have in your body or the more oxidants you have in your body the more that they are going to cause damage to different cell parts

Maiese K, Chong ZZ, Hou J, Shang C (2009) The vitamin nicotinamide: translating nutrition into clinical care

B.ThorpeK.ChenY.et al

Acknowledgements This project was supported by the National Natural Science Foundation of China (82272232, 82170775, 82370765, 82270802, 82100806, and 82300766) and the Open Project of Hubei Key Laboratory (2023KFZZ009)