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Results: The results of the present study revealed a significant increase in TSH hormone (2.23 0.44) and epinephrine hormone (371.74 24.29) in the hypothyroid group compared with the control group, while there is a significant decrease in cortisol hormone (88 17.97) and vitamin B12 (297.52 12.51) in the hypothyroid group compared with the control group, where the level of hormones in the (hypothyroid rats +B12) group became close to the level of hormones in the control group as well as significantly decreased TSH and epinephrine levels and increased cortisol and vitamin B12 serum levels

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