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Based on general GLP-1 timelines , anti-inflammatory effects likely begin within weeks, but meaningful symptom changes may take 2 to 3 months as both direct effects and weight-mediated estrogen reduction accumulate

Treatment is observation, NSAIDs, and physical therapy for mild symptoms

When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases

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