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Nat Rev Mol Cell Biol 2011;12:914

Genetic variability plays a significant role, as differences in genes associated with oxidative stress response can impact how individuals metabolize antioxidants

Conditions associated with subnormal 5-NT levels Lead poisoning Lead exposure can lead to subnormal levels of 5-NT due to direct inhibitory effects on the enzyme in serum 120,121 and red blood cells

A disruption of GSH homeostasis could induce oxidative stress and lead to neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinsons disease, Alzheimers disease, and dementia, with impaired motor and cognitive functions [7]