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Disclosures: Manasa Ginjupalli: Nothing to Disclose, Anuj Sharma: Nothing to Disclose, Fnu Vikash: Nothing to Disclose, Vikash Kumar: Nothing to Disclose, Gautam Maddineni: Nothing to Disclose, Arnold Nongmoh Forlemu: Nothing to Disclose, Jayalekshmi Jayakumar: Nothing to Disclose, Camelia Ciobanu: Nothing to Disclose, Ali Wakil: Nothing to Disclose, Amr Dokmak: Nothing to Disclose, Vijay Bhaskar Reddy Gayam: Nothing to Disclose, Praneeth Bandaru: Nothing to Disclose, Khalid Aloum: Nothing to Disclose, Raissa Nana Sede Mbakop: Nothing to Disclose, Lisnaldy Ramirez: Nothing to Disclose, Denzil Etienne: Nothing to Disclose, Madhavi Reddy: Nothing to Disclose 1913 MUTATED-Β- CATENIN DRIVES SUPPRESSION OF AN IMMUNE-REGULATORY MODULE OF TRANSCRIPTION FACTORS ALTERING EXPRESSION OF KEY CHEMOKINES INVOLVED IN IMMUNE RESPONSE IN HEPATOCELLULAR CANCERS Brandon Lehrich 1 Junyan Tao 1 Evan Delgado 1 Catherine Cao 1 Tyler Yasaka 1 Yuqing Liu 1 Minakshi Poddar 1 Sucha Singh 1 Xiangnan Guan 2 Hartmut Koeppen 2 Silvia Liu 1 Yulei Wang 2 Satdarshan (Paul) Monga 1 , 1 University of Pittsburgh, 2 Translational Medicine, Genentech Inc., San Francisco, CA, USA Background: Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related mortality worldwide

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The structures of TH in the absence of dopamine and the pSer40 state are known