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In vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy

In retinol metabolism, Rol, the metabolic substrate, undergoes a two-step dehydrogenation reaction to generate the active metabolite atRA, which then primarily binds and activates RARs (ligand-induced transcription factors) to exert biological effects 10

(2025) 60:107086.e8

There are currently 141 million adults with diabetes in China, and it is expected that by 2045, more than 174 million people will have diabetes ( Patients with diabetes are at a significantly higher risk of cardiovascular comorbidities owing to long-term metabolic disorders, persistent high glucose status, and insulin resistance (IR)

Effect of hypertonic saline on mucociliary clearance and clinical outcomes in chronic bronchitis