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The abnormal extracellular matrix and tumor vasculature surrounding tumor cells result in uneven drug distribution within the tumor, thereby reducing the effective drug concentration ( CAFs play a critical role in tumor progression and drug resistance by secreting growth factors and cytokines that promote tumor cell proliferation and migration

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As critical players in neuroinflammatory and neurodegenerative disease, microglia have become an important target for neurological diseases 11,17

The absence of long-term safety studies for most NPs, some of which have been fully developed for years, corroborates this dilemma