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5) Digestive Function Tetrahydrobiopterin is essential for serotonin synthesis

Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, Motyer A, Vukcevic D, Delaneau O, OConnell J, et al

doi: 10.1056/NEJMp1212667 [DOI] [PubMed] [Google Scholar] Palmer, K., & Florko, N

Bidirectional transmission in the GBA plays a major role in modulating brain dysfunction, maintaining symbiosis with the host and modulating innate as well as adaptive immune responses The normal gut microbiota synthesizes microbial metabolites and neurotransmitters that interact with host cells including intestinal epithelial cells (IECs) and immune cells

& Nagelkerke, A