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An effect on glutamate release is probably more significant than blockade of AMPA responses (see Chapter 21 )

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Gastrointestinal discomfort Skin irritation Allergic reactions Hypopigmented skin patches Lightened hair colour Glutathione is a naturally occurring antioxidant

The same reduced-IGFBP-binding property that produces enhanced in vivo potency in animal studies also produces enhanced cell-culture activity, because the IGFBPs secreted into serum-free media by cultured cells otherwise reduce the bioavailability of native IGF-1 supplementation

This immune privilege is attributed to their low expression of major histocompatibility complex class II molecules (MHC-II, specifically HLA-DR) and the absence of co-stimulatory molecules (CD80/CD86), supporting their capacity for immune evasion (Khoury et al., 2014)