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Any sensation is usually brief and well-tolerated

Prevailing Role of Contact Guidance in Intrastromal T-Cell Trapping in Human Pancreatic Cancer

Additional mechanisms reinforcing this shift include downregulation of the mitochondrial pyruvate carrier, which limits pyruvate entry into mitochondria [204] and activation of AMP-activated protein kinase (AMPK) in response to reduced ATP/AMP ratios, leading to mTOR suppression and metabolic stress adaptation [205,206,207]

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Moreover, TDNPs have been verified to activate the Nrf2/HO-1 signaling pathway to promote the proliferation and migration of fibroblasts by improving their endogenous antioxidant capacity and reducing cell apoptosis [40]