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This indirect effect can significantly impact pigmentation over time

They have been evolutionarily sculpted to optimize motility and, therefore, fertility, through the dynamic and challenging environment of the female reproductive tract

Aspartame would be expected to be highly mobile and not readily absorb to soils, sewage sludge or sediments (EFSA, 2021)

Gastrointestinal bleeding was a major cause of death in the past, but with prophylactic use of histamine H 2 receptor blockers and proton pump inhibitors, the incidence of gastrointestinal bleeding has been significantly reduced

Other rare adverse effects include: skin hyperpigmentation liver injury Stevens-Johnson syndrome, a potentially life-threatening blistering skin condition