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10.1038/s41586-025-08713-9 36 DongY.WangY.ZhangF.MaJ.LiM.LiuW.et al (2024)

Vagus nerve stimulation (VNS) has emerged as a groundbreaking therapy with the potential to revolutionize the treatment of numerous conditions

The antidepressant fluoxetine (Prozac) modulates estrogen signaling in the uterus and alters estrous cycles in mice

It has two main pathological characteristics, one is senile plaques mainly composed by amyloid- (A) peptides which is resulted from aberrant amyloid precursor protein (APP) cleavage, and the other is neurofibrillary tangles (NFTs) basically consisting of paired helical filaments (PHFs) which are derived from hyperphosphorylated tau proteins (Tseng et al., 2002)