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The use of post-mortem human donor tissue suffers from an inconsistent supply of cataractous lenses ( As a consequence of these challenges to utilising human tissue in cataract research, animal models have been used to investigate the underlying mechanisms of cataract formation ( Animal models that mimic the distinctly different cataract phenotypes observed in ARN cataract ( 1.2 UV light in human cataract formation: exposure, epidemiology, and effects of aging UV radiation is a known toxin to biological tissues and is classified as a carcinogen ( Three main types of tissue damage can result from light exposure

10.1002/ptr.5631 23 DuR.YunQ.WangY.DouX.YeH.WangJ.et al (2024)

Vulnerable urban populations, including homeless and those residing in low-income settings, are exposed to a potent mix of biological insults due to factors like poor ventilation in shelters, household crowding, and limited access to healthcare, all of which facilitate disease transmission

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Massague and Wotton, 2000), other means have been recognized for TGF- signaling to shape cell behavior, such as epigenetic modification, mRNA splicing and miRNA expression ( As a network of chemical reactions essential for sustaining life, metabolism has long been centered in energy provision, building of blocks for biomacromolecules and elimination of compounds that are otherwise toxic to the organism