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While O 2 itself is not directly microbicidal, it drives critical ionic fluxes that alkalinize and hypertonify the phagosomal lumen

This was manifested as a pronounced rightward shift in the melting temperature of the protein, indicating that the binding of LicoA enhances the thermal stability of Nrf2

Firstly, it directly neutralizes free radicals due to its unique chemical structure, which allows it to donate electrons and stabilize these highly reactive molecules

This subsequently contributes to the intracellular accumulation of ferric ions, along with the generation of large amounts of ROS

The combination produces faster, more durable pigment clearance than either approach alone