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Stevenson E, Minton NP, Kuehne SA

Erastin, one of the earliest discovered ferroptosis inducers, inhibits system Xc - (SLC7A11/SLC3A2), thereby impairing GSH synthesis, leading to ROS accumulation and inducing GBM cell death ( 2+ levels, increased GSH levels, and suppressed expressions of ferroptosis-related proteins such as GPX4, NRF2, and SLC7A11 ( RAS-selective lethal 3 (RSL3) is a known ferroptosis inducer

Ultimately, protoporphyrin ferrochelatase (PpfC) catalyzes the insertion of Fe 2+ into protoporphyrin IX to produce heme

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The combination of the TP53 inhibitor Eprenetapopt with conventional anticancer agents has a better therapeutic effect [269, 270]