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Cellular toxicity and immunogenicity are significant drawbacks associated with the use of cationic LNPs, particularly when repeated administration is required 61

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It penetrates the outer skin layers and acts locally on skin cells, fibroblasts, and the extracellular matrix

Research shows women can lose up to 30% of their skin collagen in the first five years post-menopause, a rate more closely tied to oestrogen deficiency than to chronological age