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Patients who have early Leber's disease (hereditary optic nerve atrophy) have been found to suffer severe and swift optic atrophy when treated with vitamin B12

Compared to hGH, AOD9604 offered similar adipose tissue effects without significantly increasing systemic growth factors, such as IGF-1

Demonstrating why their combination is mechanistically sound

The relationship between NAM metabolism and NAD + utilization indicates that elevated NNMT expression may inhibit energy expenditure and promote fat deposition by limiting NAD + -dependent processes (Trammell and Brenner, 2015)

This depth of human trial evidence provides greater confidence in safety characterization compared to peptides with primarily theoretical or animal-based safety data