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Inhibitory effects of leflunomide therapy on the activity of matrixmetalloproteinase-9 and the release of cartilage oligomeric matrix protein in patients with rheumatoid arthritis

Mechanistically, BEO appears to act as a psychostimulant, influencing ascending neurotransmitter systems involved in arousal, including serotonergic, cholinergic, noradrenergic, and histaminergic pathways

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However, this adaptation eventually decompensates, leading to mitochondrial damage, oxidative stress, and impairment of insulin signaling thereby reinforcing a vicious cycle [344]