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Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals

Saari (98) demonstrated that dietary copper deficiency resulted in various cardiovascular defects with systemic effects including hypertension, increased inflammation, anaemia decreased blood clotting and possibly atherosclerosis, which also has effects on specific organs or tissues such as diminished structural integrity of the heart and blood vessels, impaired energy use by the heart, decreased contractility of the heart, altered ability for blood vessels to control their diameter growth and structural-functional changes in circulating blood cells

doi:10.1146/annurev.nutr.20.1.457 ^ Witard O.C., Hearris M., Morgan P.T

doi: 10.1093/jxb/erac009 73 MilevNBRheeSGReddyAB

PC-3: prostate cancer cell line In human gastric cancer cell line gastric adenocarcinoma (AGS), lutein inhibited viability and colony formation in a dose-dependent manner