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Active site residues C46 (oxidized), L48, Q81, and W136 are highlighted and shown as sticks

NADPH is the principal reductant used to maintain the redox states of both the Trx and GSH systems

GST non-enzymatic functions GSTs are also implicated as modulators of signal transduction pathways implicated in cell survival and apoptosis, where they control the activity of members of the mitogen-activated protein kinase (MAPK) family 24,25