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Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants

It has been associated with reducing the risk of certain chronic diseases and supporting cardiovascular health

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An increasing body of evidence suggests that disturbances in the pulmonary mechanical microenvironment, a complex interplay of extracellular matrix (ECM) stiffness, alveolar surface tension, cellular forces, and cell-matrix interactions, play a crucial role in the pathogenesis and progression of these diseases ( Owing to their unique size and highly tunable physicochemical properties, nanomaterials present unparalleled opportunities to finely adjust the pathological microenvironment within the lungs ( Here, we explore how nanomaterials can address dysregulation in the lungs mechanical microenvironment by modulating ECM properties, normalizing alveolar surface tension, and influencing mechanotransduction pathways in pertinent lung cells

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