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The retinoblastoma gene (Rb) encodes a tumour suppressor protein critical for controlling the G1 checkpoint of the cell cycle, which regulates the transition from G1 to S phase

(2021) 220:e202105043

doi: 10.1016/j.bbabio.2017.09.004 183 HongSZhangXLakeRJPawelGTGuoZPeiRet al

However, despite the absence of ferritinophagy we found that intracellular ferrous iron levels in IB3-1 cells (but not C38 cells) increased following erastin and FAC exposure, which requires further investigation as the pathways responsible for this increase in redox active iron in response to ferroptotic induction are currently unknown, but will become targets for future treatment interventions