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Multiple classes of advanced therapies, including both monoclonal antibodies and novel oral small molecules, are now available for the treatment of moderately-to-severely active Crohns disease and ulcerative colitis, highlighted by the approvals of the first IL23p19 antagonists, selective Janus kinase inhibitors and sphingosine-1-phosphate receptor modulators

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In 2023, the FDA classified BPC-157 as a Category 2 bulk drug substance, restricting its use by compounding pharmacies

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