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Ozempic potentially dethroned by CagriSema, but weight loss still wins CagriSema: Phase 3 Results, Dosing, Side Effects & 2026 FDA Update New trial data on CagriSema 23% weight loss at 84 weeks in the RE DEFINE 4 trial. CagriSema pairs semaglutide with cagrilintide, an amylin analogue. Amylin is a pancreatic hormone that slows Cagrilintide is an amylin analogue that helps regulate appetite. In a randomized trial of over 3400 patients who were overweight or obese and had 1 weight related complication, individuals assigned to a combination CagriSema obesity drug: what the phase 3 data shows
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