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Surface plasmon resonance (SPR) experiments SPR measurements were performed by the Imp@ct core facility (SFR bonamy, Nantes Universit, CNRS, Inserm, Nantes, France) to characterize the interaction between the chemical compound of interest NXP800 and recombinant human protein GCN2 fused to glutathione S-transferase (GCN2GST

Red lines indicate the mean intensity in each group

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Recent evidence suggests that a number of these manifestations may be linked to an unfavorable impact of the disease on the mitochondrial function of various tissues and organs (18,22)

Immunofluorescence (IF) studies indicated that those transplanted GMSCs integrated into the wall matrix of NPs and localized in the peripheral areas outside of the injured nerves as recognized by the positive expression of human nuclei, whereas only about 5% of them were positively stained for the active form of caspase-3 (Additional file 1: Fig