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In LPS-induced PE models, we observed significant downregulation of pathways involved in amino acid metabolism (including glutathione and histidine metabolism)key for maintaining redox homeostasis, energy production and pathways including VEGF and cell adhesion

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Administration of nintedanib immediately or 3 days after UUO injury and with folic acid injection attenuated kidney fibrosis and inhibited activation of renal interstitial fibroblasts