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doi: 10.2174/011574888X365639250214045110, 115 PapadimitriouC.CelikkayaH.CosacakM

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In some individuals, usually adults, acetaminophen can induce a high-anion-gap metabolic acidosis secondary to 5-oxoproline (ie, acquired pyroglutamic academia), possibly because of a genetically determined propensity (54

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Also, NCOA4-mediated ferritin degradation was reported in the brains of aging mice [330]

Very long-term continuous use (months to years) is not well-characterized and should be undertaken only with appropriate oversight, full tracking, and clear research objectives that justify the extended duration