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Conversely, in type 2 diabetes, the body may still produce insulin, but it is either insufficient to meet the body's needs or the body's cells are resistant to its effects

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However, this process is non-selective and influenced by regional differences in receptor density, blood flow, and hormonal sensitivity

A total of 112 patients (10 studies) received cyclophosphamide, with an ORR of 49% (95% CI, 35-64), which was higher when cyclophosphamide was combined with corticosteroids (48%) and used in second-line treatment (58%) than in monotherapy (31%), and in first-line treatment (44%)