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Think of it like refilling a reservoir that has run completely dry

There is no robust evidence that sublingual preparations offer a clinically meaningful advantage over standard oral tablets at equivalent doses

American Family Physician, 96(6), 384-388

We have shown previously that sirtuins SIRT1 and SIRT3 have anti-fibrotic function, and their decreased tissue expression observed in skin biopsies from SSc patients, might directly contribute to the persistence of fibrosis 28,29